Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses
نویسندگان
چکیده
منابع مشابه
Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo.
Type I interferon (IFN) induction is an immediate response to virus infection, and very high levels of these cytokines are produced when the Toll-like receptors (TLRs) expressed at high levels by plasmacytoid dendritic cells (pDCs) are triggered by viral nucleic acids. Unlike many RNA viruses, respiratory syncytial virus (RSV) does not appear to activate pDCs through their TLRs and it is not cl...
متن کاملProduction of interferon in respiratory syncytial virus bronchiolitis.
Production of interferon alfa in vitro was significantly reduced during acute respiratory syncytial virus bronchiolitis but subsequently returned to normal. Nasopharyngeal and endotracheal interferon alfa were detected intermittently and in low concentrations. The degree of impairment of in vitro production and poor in vivo production of interferon alfa suggest the need for a therapeutic trial ...
متن کاملInterleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitor activity
Respiratory viral infections are commonly associated with altered immune responses, such as proliferative responses to mitogens and antigens. To examine potential mechanisms, we examined production of IL-1 and IL-1 inhibitors by purified human peripheral blood-derived macrophages exposed to influenza virus or respiratory syncytial virus (RSV). IL-1 and IL-1 inhibitor activities in supernatant f...
متن کاملInfluenza and respiratory syncytial viruses: Efficacy of different diagnostic assays
OBJECTIVE To determine the efficacy of cell culture, immunoflourescence Assay (IFA) and real time polymerase chain reaction (rRT-PCR) in relation to diagnosis of influenza and Respiratory Syncytial Virus (RSV). METHODS Total 2781 specimens of throat swabs and nasopharyngeal aspirates were obtained from patients suspected of respiratory viruses' infections from January 2009 to December 2011 at...
متن کاملRespiratory illness associated with influenza and respiratory syncytial virus infection.
AIMS To estimate excess morbidity during periods of influenza and respiratory syncytial virus (RSV) activity. METHODS Retrospective analysis of a sentinel practice network database in active and non-active virus periods. MAIN OUTCOME MEASURES clinical diagnoses of new episodes of influenza-like illness (ILI), acute bronchitis, asthma, and otitis media. RESULTS The clinical diagnosis of IL...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1981
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.32.1.300-303.1981